The development of applied undergraduate education is the requirement of our country's economic development and social progress, and it is also an irreplaceable part of China’s higher education. In order to better cultivate applied undergraduate talents with innovation consciousness and ability, solid professional theory and strong operation ability, the reform of chemical engineering and technology major was put forward from the following six aspects: formulating the training program of application type, introducing a new model of flipped classroom teaching, strengthening cultivation of students' innovation and entrepreneurship ability, perfecting construction of training base in school，strengthening the cooperation between schools and enterprises and building applied undergraduate teaching staff. Good results have been achieved.