In recent years, some related studies are mainly focused on introduction and teaching methodology of flipped classroom. There are few researches of flipped classroom done from the empirical perspective. An empirical study was taken on flipped teaching practice of college English course in Beijing Institute of Petrochemical Technology. The study reflected on the problems in existence and endeavored to do research again in terms of actual situation. We took a change in guiding students in accordance with their concrete English proficiency and aptitude, adjusting the specific operating mode of flipped classroom, relocating the roles between teachers and students, making pointed and workable teaching videos, figuring out feasible practical procedures and methods on flipped classroom, so as to make it truly serve college English teaching and improve the comprehensive proficiency of students in English learning.